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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well lead to a rise in methadone plasma concentrations, which could induce perhaps deadly respiratory depression. Furthermore, discontinuation of concomitantly applied cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also cause a rise in methadone